• 专利附录
  • 专利说明
  • 权利要求
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    • 专利摘要:
    The invention relates to a spring assembly for an administering device, comprising a spring, which is designed as a drive or coil spring, and a spring shaft with a fixed flange, wherein the inner end of the spring is at least rotationally fixed to the shaft. Further, the spring assembly comprises a spring sleeve which at least partially surrounds the jacket portion of the spring, wherein the outer end of the spring is rotatably connected to the spring sleeve, and a disc-like Federhülsendeckel which axially fixed to the spring sleeve or the spring shaft can be attached, wherein the plate diameter the spring sleeve cover is equal to or smaller than that of the spring sleeve. The spring shaft defines an axis, has proximal and distal ends, with the flange and spring sleeve covers extending radially away from the axis, and the flange disposed proximate the distal end of the spring shaft. Furthermore, at least one radial stop is arranged on the periphery of the flange, and at least one blocking means is arranged on the spring sleeve complementary to the at least one radial stop, so that upon engagement of blocking means and radial stop, the spring sleeve and the spring shaft are secured against rotation relative to each other and detachably become. Further, the invention relates to associated delivery devices and methods for assembling spring packs in delivery devices.
    公开号:CH711270A2
    申请号:CH00531/16
    申请日:2016-04-21
    公开日:2016-12-30
    发明作者:Schrul Christian；Tschirren Markus；Schenker Susanne；Hostettler Patrick；Streit Ursina
    申请人:Tecpharma Licensing Ag；
    IPC主号:
    专利说明:

    The present patent application relates its priority date of the patent application 00 904/15 (CH), which was filed on 23.06.2015 at the Federal Institute of Intellectual Property in Switzerland and which hereby incorporated by reference into the present application in full is integrated.
    The invention relates to a spring assembly for an injection device, a corresponding injection devices and a method for mounting these injection devices. In particular, the invention relates to an improved drive unit for an injection device and a method for mounting this drive unit in the injection device.
    As used herein, the term "drug" or product includes any fluid medical formulation suitable for controlled administration by an agent, such as an agent. a cannula or hollow needle, for example, comprising a liquid, a solution, a gel or a fine suspension containing one or more medicinal agents. Drug may be a single drug composition or a premixed or co-formulated multi-drug composition from a single container. Drug or product includes drugs such as peptides (eg insulins, insulin-containing drugs, GLP-1 containing as well as derived or analogous preparations), proteins and hormones, biologically derived or active agents, hormone or gene based drugs, nutritional formulas, enzymes and other substances but also in solid (suspended) or liquid form but also polysaccharides, vaccines, DNA or RNA or oligonucleotides, antibodies or parts of antibodies as well as suitable bases, excipients and carriers.
    From WO 2014/170 267 injection devices with a compact energy storage are known. The energy store comprises at least two interconnected coil springs which may have stored enough energy, i. are biased to empty a whole drug container. The document does not disclose details of how the coil springs can be biased.
    From WO 2014/154 491 an energy storage unit for an administering device is known. This energy storage unit comprises a preloaded compression spring, wherein the unit has a transport lock, which is intended to prevent unwanted activation of the energy storage unit. For the administration of viscous drugs compression springs must be large and long dimensions, so that the delivery devices must be sized larger. In order to achieve a regular administration of medicament then compression springs must be strongly biased, which increases the risk of glass breakage in triggering the delivery device when using glass syringes as a drug container.
    It would therefore be desirable to have available energy storage units which would be easy to transport with stored energy and would also be geometrically adaptable to known delivery devices.
    It is therefore an object of the invention to provide an improved energy storage for an administering device, which allows the dispensing of high-viscosity drugs and thereby is cost-effectively produced as well as a cost-efficient production of the administering device allowed.
    The object is achieved with a spring assembly, an administration device, and a method for assembling a spring assembly according to claims 1,10 respectively 11. Advantageous developments emerge from the dependent claims, the description and the figures.
    In one aspect, the invention relates to a spring assembly for an administering device comprising a spring, which is designed as a drive or coil spring and a spring shaft with a fixed flange, wherein the inner end of the spring is mounted at least rotationally fixed to the shaft. Further, the spring assembly comprises a spring sleeve which at least partially surrounds the jacket portion of the spring, wherein the outer end of the spring is rotatably connected to the spring sleeve, and a disc-like Federhülsendeckel which axially fixed to the spring sleeve or the spring shaft can be attached, wherein the plate diameter the spring sleeve cover is equal to or smaller than that of the spring sleeve. The spring shaft defines an axis, has proximal and distal ends, the flange and spring sleeve covers extending radially away from the axis, and the flange positioned proximate the distal end of the spring shaft. Furthermore, at least one radial stop is arranged on the periphery of the flange, and at least one blocking means is arranged on the spring sleeve complementary to the at least one radial stop, so that upon engagement of blocking means and radial stop, the spring sleeve and the spring shaft are secured against rotation relative to each other and detachably become.
    In a further aspect, the invention relates to a spring assembly in which the axial positioning of the spring by the fixed position of the flange, and a variable axial fixation of the spring sleeve cover is defined and thereby springs with different axial extent can be used in the spring assembly.
    In a further development of the spring sleeve cover can be moved into the spring sleeve, wherein the spring sleeve cover has at its periphery at least one snap element, and the spring sleeve complementary thereto at least one receptacle for the at least one snap element to secure the spring sleeve cover to the spring sleeve ,
    Wherein, in a further development, the spring sleeve comprises a plurality of axial positions at least one receptacle for the at least one snap element of the spring sleeve cover, so that the spring sleeve cover can be fixed in different axial positions on the spring sleeve.
    In one aspect, the spring may consist of spirally rolled-up strip material, preferably of metallic strip material, particularly preferably of strip-shaped steel.
    In a further aspect, the invention comprises a spring assembly as described, wherein the spring sleeve is arranged coaxially to the spring shaft, characterized in that on the spring sleeve at least one flexible arm is arranged, which extends in the circumferential direction of the spring sleeve, which with one end is fixedly attached to the spring sleeve and can be deflected in the radial direction at the other end and wherein the blocking means, in particular in the form of a tooth is arranged at the free end, which by deflection of the at least one flexible arm of the flexible arm in engagement with the radial stop can be brought or released from the intervention, so that the flexible arm can form a Sperrschnapper together with the blocking means. Further, a control arm can be arranged axially offset in the distal direction of the blocking means at the free end of the arm, and wherein, in the case of radial deflection of the control arm, the blocking means is moved correspondingly radially and vice versa.
    In another aspect, the spring shaft having an axially formed retaining rib, in which the formed as a retaining tab inner end of the spring can be rotatably anchored, and wherein the spring sleeve has an axially oriented support structure on which the formed as a retaining tab outer end of the Spring can be anchored rotatably.
    The spring can be biased according to an embodiment by relative rotation of the spring sleeve to the spring shaft, said bias can be maintained by engagement of radial stop and blocking means, wherein the bias can correspond to a torque of 1 to 100 Nmm, preferably a torque from 30 to 80 Nmm and may particularly preferably correspond to a torque of 60 to 70 Nmm.
    In one aspect, the invention relates to an administration device for administering a fluid product, the delivery device comprising a longitudinal axis and a housing having a mechanism holder which is fixedly connected to the housing. Furthermore, the administration device comprises a triggering device and a product container, in particular in the form of a prefilled syringe or carpule, which is arranged at least axially fixed in a part of the housing, wherein in the product container an axially displaceable plug is arranged by its displacement in the distal direction of product can be distributed to the product container. Still further, the administering device comprises a spring assembly according to the invention, in which energy is stored for the automatic dispensing of product, wherein the spring assembly is operatively connected to the triggering device, and wherein the spring sleeve is rotatably connected to the housing, a threaded rod arranged coaxially with the longitudinal axis rotatably connected to the spring shaft, a coaxial with the longitudinal axis arranged piston rod which is guided axially displaceable and rotationally fixed in the mechanism holder, wherein the piston rod with the plug of the product container can interact so that during axial movement of the piston rod in the distal direction and the plug in the distal Direction can be moved, the piston rod is constructed like a sleeve and is threadedly on an inner surface of the piston rod in threaded engagement with the threaded rod, so that a rotation of the threaded rod, an axial displacement of Kolbensta result in
    Further, the invention relates to a method for mounting a spring assembly with a biased drive or coil spring in an administration device for administering a fluid product, in particular an elongated injection device, comprising a housing and a housing-fixed mechanism holder comprising at least the following steps:The spring pack is pushed axially onto a preassembled drive unit of the administering device comprising the mechanism holder, whereby a rotatable drive member provided in the drive unit is secured against rotation with a spring shank of the spring pack, and thereby firmly attached to the mechanism holder arranged release element in front of a control arm of the spring assembly pushes<b> <b> <SEP> A housing part or termination part of the administering device is pushed axially in the distal direction over the spring assembly, whereby the outer shell surface of the spring assembly is connected in a rotationally secured manner to the housing part or end part.the housing part or end part is twisted relative to spring assembly and preassembled drive unit, whereby the guide elements of the mechanism holder are guided in guides of the housing part or end part, wherein the guide runs along the circumference of the housing part or end part, wherein Rotation of the release member moves the control arm outward in the radial direction and thus releases a torque present in the spring assembly, whereby further relative rotation between the housing or end part and the mechanism holder evokes until a radial block of the spring assembly engages with a radial stop of the mechanism holder and so a non-positive connection between spring assembly and mechanism holder is generated.
    In one aspect, the invention relates to an administering device, which has been mounted according to the preceding paragraph described method, wherein the drive or coil spring is wound so that the torque acting on the outer surface of the spring assembly after the release of the torque, has in the opposite tangential direction compared with the circumferentially extending portion of the guide on the housing part.
    In one aspect, the invention relates to an administering device which has been assembled according to the method described above, wherein the administering device is an autoinjector or an injection pen with automatic administration.
    In one aspect, the invention relates to an administering device which has been assembled according to the method described above, wherein the administering device is a "patch" device.
    The term "distal" refers to the geometric end delivery device on which the drug exits upon administration. The term proximal thus refers to the opposite end. In a pen-like injection device, the distal end corresponds to that with the injection needle tip.
    The term "radial stop" refers to a stop which can prevent relative rotation between two parts. A radial stop, for example, consists of a two-dimensional structure whose surface normal is tangent to a circle virtually generated by the rotation.
    In one aspect of the invention, a spring assembly for an administering device is disclosed, which consists of at least one spring shaft, a spring, in particular a spiral or clock spring, and a spring sleeve. The spring can be mechanically tensioned and subsequently exert a torque on the spring shaft or spring sleeve. The spring is connected at one end to the shaft and at the other end to the sleeve.
    In an advantageous arrangement, the spring is a spiral spring, which is wound around the spring shaft and whose inner end is connected to the spring shaft. In this arrangement, the outer end of the spring is connected to the spring sleeve, wherein the spring sleeve for the spring forms a sheath. In this arrangement, the spring can be tensioned, in which the spring sleeve is rotated relative to spring shaft.
    In an advantageous arrangement, the spring sleeve can be secured relative to the spring shaft against rotation. Here, a blocking element can be fixedly arranged on the spring sleeve and the spring shaft, a complementary thereto trained element be fixed - which can work together to prevent rotation. By moving one of the elements then the rotation can be solved. The blocking element may in particular be designed as a Sperrschnapper, which can engage in a radial stop on the spring shaft. In this case, the Sperrschnapper be arranged as a flexible arm on the spring sleeve or be part of the sleeve. At a free end of the arm can then be arranged, for example, a tooth, which can be brought into engagement with the radial stop. The engagement between stop and tooth can be achieved by a movement of the free end of the arm, in particular a movement in the radial direction to the outside.
    In an advantageous combination, the spring assembly may include a preloaded spring, wherein the spring tension of the above-described Vedrehsicherungen can be maintained. In an advantageous addition, the spring assembly comprises a cover and a bottom element. In a further development, the bottom element is arranged as a flange fixed on the spring shaft and the cover element is formed as a separate element which can be fixed at a variable distance from the bottom element on the spring shaft and / or on the spring sleeve, that the spring are protected from external mechanical influences can. As a result, the spring pack can be transported with preloaded spring. The spring can also be supported and / or guided by the bottom and / or cover element in the axial direction. In an alternative embodiment, the spring pack may also contain two, three or more preloaded springs, preferably with a cover element for each spring.
    In an advantageous arrangement, the spring consists of spiral-shaped strip material, wherein the spring parameters, such as the spring constant, are determined among others by the width of the strip. The above beschiebenen arrangements allow advantageously different stiff springs with identical spring shaft (also with flange) to install identical spring sleeve and identical cover element. The strip material used may be metal, in particular steel, or plastic.
    In a further aspect of the invention, an administering device is disclosed in which a spring assembly can be installed according to one of the above arrangements, wherein the spring assembly can serve as a drive means. The type of administration device can be a pen-like injection device with a medicament storage, in particular an autoinjector or an autopen. In this case, the pen-like injection device can be designed for the administration of exactly one dose or several doses. Also, the injection device may comprise a means with which the size of the dose can be selected specifically. The spring assembly is biased in advantageous forms, so that the drug storage can be partially or completely disseminated by the energy stored in the spring. In another interesting embodiment, more energy is stored in the spring pack than is needed to administer a medication store. As a result, the spring assembly can be used in particular in reusable injection devices. Alternatively, the spring pack can also be designed so that the spring can be tensioned by a user, for example, when changing the drug reservoir or when setting a dose.
    In an alternative aspect, an administration device is disclosed, in which a spring assembly can be installed according to one of the above arrangements, wherein also here the spring assembly can serve as a drive means. In this alternative aspect, the type of administering device can be an injection or infusion device, which can be applied directly to the skin of a patient by means of an adhesive bond in particular. Such devices are known in the art as "patch injector" or "patch pump". In a further embodiment of the aspect, the spring assembly can serve not only as a drive means for the administration process, but also or alternatively as a drive means for piercing the administration cannula through which a product is administered.
    In another aspect of the invention, a method of assembling a spring pack into an administering device is disclosed. In this case, the administration device can be a pen-like injection device. Alternatively, it can also be the above-mentioned "patch" devices.
    In an advantageous embodiment of the method for mounting the spring assembly in the administering device, it is in the administration device to a pen-like injection device, in particular an autoinjector or an autopen. During assembly of the spring assembly, the spring assembly is arranged on a preassembled drive unit as described. The preassembled drive unit consists at least of a spring receptacle, in particular a mechanism holder, and a movable, in particular rotatable, arranged in the spring receptacle or mechanism holder drive member. In an embodiment with a mechanism holder, the drive member may be a threaded rod which has a longitudinal guide at its proximal end.
    In this embodiment, the spring assembly is pushed onto the proximal end of the preassembled drive unit in a first assembly step. The threaded rod described is brought to the spring shaft in a non-rotating connection, so that a rotational movement of the shaft is transmitted to the threaded rod. In the spring package blocking means of the spring sleeve and the complementary element in engagement in this state, so that the spring of the spring assembly can be biased. On the mechanism holder a release element is further arranged, which passes when pushing the spring assembly relative to the blocking agent in a release position. Starting from this triggering position, a further relative movement between the release element and blocking means is possible, by means of which the engagement between the blocking means and the complementary element is released. In this so-called triggered position, a relative rotation between the spring shaft and spring sleeve is now possible, which means that in this state, torque can be conducted from the spring to outside the spring assembly.
    In a second assembly step, a housing part of the injection device is pushed in the distal direction over the spring assembly and at least partially over the preassembled drive unit. The spring sleeve is secured against rotation to the housing part. Next, a connection between the mechanism holder and a housing part is made, which firmly connects in the following consequence, housing and mechanism holder of the injection device.
    In an advantageous embodiment of the connection between the mechanism holder and the housing part, the connection is made by a bayonet lock. This type of connection has the advantage that in the preparation of the fixed connection and the release element of the mechanism holder can be moved from the release position to the triggered position. For this purpose, can be arranged on the periphery of the mechanism holder bayonet cams, which can get into engagement with bayonet grooves on an inner surface of the housing part. The bayonet grooves have at least one part, which extends axially and at least one further portion, which extends in the circumferential direction. In the second assembly step, the bayonet grooves come into engagement with the axialverlaufenden part of the bayonet grooves, so that the housing part can be pushed over the mechanism holder. At the end of this movement, the spring sleeve is secured against rotation with the housing part.
    In the following third assembly step, the mechanism holder is rotated relative to the housing part, wherein the movement is guided by the proportion of the bayonet groove which extends in the circumferential direction and wherein the bayonet is closed. At the same time, since the spring sleeve is now secured against rotation to the housing part, a relative movement between the mechanism holder and spring sleeve takes place, with the result that the release element is moved from the release position to the triggered position.
    In an alternative embodiment, the spring receptacle can also be connected via a Schnappververbingung with a trained as a final part housing part. Wherein the snap replaces the first part of the bayonet lock and the final part is rotatably mounted in the spring receptacle after the snap, so that the above, third assembly step can be carried out the same as in the bayonet lock.
    Alternatively, the connection between spring receptacle and end part can also be mitgeformt by threaded parts.
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    [0039]<Tb> FIG. 1 <SEP> View of an inventive injection device with a spring assembly according to the invention.<Tb> FIG. 2a - 2b <SEP> Section view, resp. exploded view of the injection device of FIG. 1.<Tb> FIG. 3a-3c <SEP> Exterior view, sectional view, respectively exploded view of a spring assembly according to the invention<Tb> FIG. 4a-4c <SEP> External view, sectional view, respectively exploded view of a spring assembly according to the invention with an alternative embodiment of the spiral spring<Tb> FIG. 5a-5b <SEP> View of a spring assembly according to the invention from a distal position, wherein FIG. 5b shows a detail B from FIG. 5a<Tb> FIG. 6 <SEP> View of the first assembly phase<Tb> FIG. 7a <SEP> View of the second assembly phase<Tb> FIG. 7b <SEP> View of end cap with bayonet groove<Tb> FIG. 8 <SEP> View of the third assembly phase<Tb> FIG. 9a-d <SEP> Views of a spring assembly according to the invention from a distal position in three different states during assembly, wherein the mechanism holder is shown partially cut away<Tb> FIG. 10a-d <SEP> Views of the spring assembly of FIG. 9a-d wherein a distal part of the spring assembly has been cut to better show the Sperrschnapper.<Tb> FIG. 11 <SEP> Exterior view of an alternative injection device<Tb> FIG. 12a-12b <SEP> sectional and exploded view of the injection device of FIG. 11<Tb> FIG. 12c <SEP> Detailed cross-section B-B of Fig. 12b
    FIGS. 1 to 1 show an inventive spring package with a corresponding injection device, an auto-injector, and the various assembly steps of the associated method according to the invention.
    FIGS. 11-12d show thereafter the use of spring packages according to the invention in an alternative administration device, namely a so-called autopen, an injection pen with which a manually adjustable dose can be administered by stored energy.
    Referring to Figs. 1-1Od, a first series of possible embodiments of the invention based on an auto-injector 0 as shown in Fig. 1 will now be described. It is at this point the Swiss patent application 00904/15 referenced and fully integrated into the present application, since it also describes the autoinjector 0 apart from the spring package also comprehensive.
    It is now the construction and the function of the auto-injector 0 with reference to FIGS. 1 - 2b set forth. Auto-injector 0 has a sleeve-shaped, elongated housing 2 with a longitudinal axis L, which has at its proximal end a closure cap 12 which is positively connected to the housing 2 rotatably and axially fixed and forms the proximal end of the autoinjector. The closure cap 12 is snapped with the housing 2. For this purpose, the closure cap 12 a latching member 12 a, which is engaged in a recess 2 a on the housing 2, preferably so that the closure cap 12 is not or not easily detached from the housing 2.
    At the distal end of the auto-injector in its delivery state (Fig. 2a - 2b) a Abziehkappe 4 is arranged with a cap remover 4f, which deducted before using the autoinjector, unscrewed or turned off, and removed.
    In the housing 2, a product container 13 in the form of a syringe with respect to the housing 2 - apart from the assembly of the auto-injector - is taken immovably along the longitudinal axis L. The product container 13 has a sleeve-shaped syringe body, which surrounds a piston 13b, which bears sealingly against the inner circumference of the syringe body. At its distal end, the syringe body has an injection needle 13a, in particular permanently connected to the syringe body, the distal end of which is formed by the needle tip. Between the injection needle 13a and the piston 13b is a liquid product, in particular medicament, disposed within the syringe body, wherein the liquid product by displacing the piston 13b in a dispensing direction, ie in the distal direction or to the injection needle 13a out through the hollow injection needle 13a the product container 13 is poured. The syringe body has at its proximal end a so-called finger flange, which protrudes radially outward beyond the outer circumference of the cylindrical syringe body.
    The product container 13 is accommodated in a product container holder, which is referred to as a syringe holder 1, so that it is secured at least against a movement along the longitudinal axis L in the distal direction relative to the syringe holder 1. The syringe holder 1 is, as best seen in FIG. 2b can be seen, positively connected to the housing 2, in particular latched. The housing 2 has for this purpose recesses into which latching elements, which are formed here at the proximal end of the syringe holder 1, engage. The syringe holder 1 has at least one inwardly projecting shoulder 1b, on which a tapered portion of the product container 13, which is mounted distally of the cylindrical syringe body portion guiding the piston 13b, is supported.
    In order to prevent the product container 13 is displaceable in the proximal direction relative to the syringe holder 1, the product container 13 is pressed at its proximal end by a force acting on the syringe body holder into engagement with the shoulder 1 b. The holder is formed by a retaining spring portion 5 c of a mechanism holder 5. The mechanism holder 5 is in particular arranged immovably and / or rotationally fixed relative to the housing 2 along the longitudinal axis L. The sleeve-shaped mechanism holder 5 can be snapped with the housing 2. Length differences of the product container 13, which may arise due to manufacturing tolerances, can be compensated by the retaining spring section 5c, whereby the tight fit of the product container 13 to the shoulder 1b is ensured.
    The product container 13 is arranged with respect to the housing 2 so that the needle tip protrudes distally beyond the distal end of the housing 2. In the initial or delivery state of the autoinjector, i. When the peel cap 4 is placed on the autoinjector, the needle 13a is covered by a needle cap 14, which in the example shown is a so-called rigid needle shield known in the art, alternatively a soft needle shield, to project the needle 13a To protect contamination or to keep the needle 13a and the drug sterile. The rigid needle shield 14 is disposed on a needle holding portion of the syringe body with the tapered portion of the syringe body between the needle holding portion and the cylindrical portion of the syringe body. The peel-off cap 4 is detachably snap-fastened to the housing 2 or a needle protection sleeve 3, this snap-fastening being released when the peeling cap 4 is removed from the housing 2 or the needle protection sleeve 3. The snapping is formed in the example shown by a snap hook 3b of the needle guard 3 and a snap geometry 4a of the peel 4. The peel cap 4 further includes, in particular, a cap remover 4f, with which the rigid needle shield 14 is released from the product container 13 and removed together with the cap 4 of the auto-injector.
    The auto-injector 0 has a needle guard 3 which is slidable relative to the housing 2 and along the longitudinal axis L about an actuating stroke HB (not shown) in the proximal direction to an actuated position to initiate product dispensing. In the starting position of the needle guard 3, as shown in FIG. 2b, the distal end of the needle guard 3 projects distally over the needle tip of the needle 13a, so that access to the needle tip is initially prevented. By moving the needle guard 3 about the operating stroke HB, the needle guard 3 is displaced in the proximal direction so far that the needle 13a protrudes from the distal end of the needle guard 3, particularly protruding with a length corresponding to the injection depth of the needle into the puncture site. The needle 13a should preferably project beyond the distal end of the needle protection sleeve 3 so far that a subcutaneous or intramuscular injection can take place.
    After the injection has been completed, the needle guard 3 can be displaced relative to the housing 2 from the actuated position along the longitudinal axis L by a needle guard stroke HN (not shown) in the distal direction to a needle guard position. In the needle protection position, the distal end of the needle guard sleeve 3 projects distally over the needle tip, so that access to the needle tip is prevented and a risk of injury is reduced. The needle guard 3 can, as will be described below, be blocked against re-pushing out of the needle guard position.
    The autoinjector 0 further comprises a particular sleeve-shaped driving member 7, which in particular has on its inside a threaded portion 7b in particular a thread segment. The propulsion member 7 is in particular rotationally fixed with respect to the housing.
    Furthermore, the autoinjector 0 comprises, as already mentioned, a rotary member 11, in particular a threaded rod 11, the rotation of which causes the spring energy to be delivered to the advancing member 7, whereby the advancing member 7 is moved in the distal direction, in particular by a screw drive. The threaded rod 11 is connected to a first spring in the form of the spring assembly 9, which stores the energy required for product distribution and releases it as needed. The threaded rod 11 is coupled to one end of the first spring 9, wherein the other end of the first spring 9 is connected to the closure cap 12.
    The threaded rod 11 is axially fixed with respect to the housing 2 and at least in one, preferably in the distal direction axially fixed to the housing part 12 (cap) support.
    By releasing the advancing member 7, the first spring 9 is allowed to move the advancing member 7 in the distal direction. The first spring 9 is a helical spring, which is biased in the initial or delivery state of the autoinjector with so much energy that it contains the product contained in the product container 13 in particular completely by turning the threaded rod 11 and with displacement of the driving member 7 to a delivery stroke HA (not shown) can pour out of the product container 13. In the state of delivery of the device, a distance exists between the piston 13b and the distal end of the advancing member 7, so that the advancing member 7 only strikes the piston 13b during the execution of the delivery stroke HA and carries it along in the delivery direction.
    In an advantageous alternative embodiment (not shown) of the threaded connection between threaded rod 11 and driving member 7, in particular the thread of the threaded rod 11 may have a variable (thread pitch, wherein in a first region, the thread may have a large pitch and different in different areas For tolerance reasons, a distance between the driving member 7 and the piston 13b can exist in the state of delivery of the auto-injector 0. During production, it is attempted to keep the distance as small as possible so that the impact of the driving member 7 on the piston 13b does not increase This distance between the advancing member 7 and the piston 13b is also called the acceleration path. In order to control the acceleration of the advancing member 7 in the acceleration path and to minimize the risk of glass breakage, a thread entry path is provided for the beginning of the piston rod movement ner large pitch especially on the threaded rod 11 and / or driving member 7 selected. Preferably, the axial portion of the thread entry path is greater than the acceleration path. Furthermore, in a storage position, the axial forces, which are caused in particular by the thread translation of the torque of the spring by a large pitch are kept low. The thread or the thread pitch can vary over the length of the threaded rod 11 and / or the driving member 7. The thread can be one or more continuous. Preferably, the thread is double-threaded. The slope can be progressive or degressive. For example, For example, a further region of the rotary member may have a smaller pitch than the first region, wherein the largest thread pitch may preferably not be self-locking. With such a varying thread, it is possible to compensate for the drop in the spring force moment and to keep the discharge force in a constant range during the discharge. It is possible that at the end of the dispensing movement, a small thread pitch is chosen and thus the dispensing force is increased, e.g. a plug friction force which can increase at the end of the payout is compensated for and a complete payout can be ensured. The rotary member and / or the driving member may have a plurality of areas with different thread pitches. For example, For example, the thread can have a large thread pitch for the thread entry and then an area with a smaller and smaller thread pitch - for a slow payout - and in an area with a small thread pitch - to ensure a complete pouring - end. As a result of the suitable design of the threaded connection, the choice of the spring 92 in the spring assembly 9 is simplified as a result of the fact that the drive train can compensate for variations in the spring force development.
    Further, the auto-injector 0 has a holding member 6, which in this example has two arms 6c, wherein on each arm 6c, a first engaging member 6a and a second engaging member 6b is arranged. The first engagement element 6a points radially to the longitudinal axis L, wherein the second engagement element 6b points radially away from the longitudinal axis L. The first engagement member 6a engages a recess 7a formed by the drive member 7, thereby preventing movement of the advance member 7 relative to the support member 6 in the distal direction or in the discharge direction. As a result, the first spring 9 is held in its tensioned state.
    The auto-injector 0 has a switching module 8, 15 which has a switching sleeve 15 and a blocking sleeve 8 surrounded by the switching sleeve 15. In the state of delivery of the device, the first engagement element 6a is held in engagement with the recess 7a by the inner periphery of the lock sleeve 8 abutting the second engagement element 6b.
    The switching sleeve 15 is connected to the proximal end 3a of the needle protection sleeve 3 or abuts at least at the proximal end 3a of the needle protection sleeve 3. A second spring 10, which preferably at least partially surrounds the shift sleeve 15 and the lock sleeve 8, is supported by its distal end on the shift sleeve 15. A part of the switching sleeve 15 is thus arranged between the needle protection sleeve 3 and the distal end of the second spring 10. The second spring 10 is acting as a compression spring and designed as a helical spring metal spring. The second spring 10 is supported with its proximal end on the holding element 6, in particular on a projection 6e, which engages axially displaceable and rotationally fixed in the housing 2 from. The second spring 10 thus also surrounds the mechanism holder 5 at least partially, preferably completely.
    The switching member 15 has a recess 15a, in which a locking member 8a of the locking sleeve 8 engages. The locking member 8a is sawtooth-shaped and projects radially away from the longitudinal axis L. The locking member 8a is resiliently arranged on an arm which is formed by the locking sleeve 8. By displacing the switching sleeve 15 in the proximal direction, the locking sleeve 8 is entrained via the engagement of the locking member 8a in the proximal direction.
    By moving the needle guard 3 in the actuated position, the shift sleeve 15 is also taken to the operating stroke HB (not shown), whereby the second spring 10 is tensioned. If the needle guard 3 is not completely displaced into the actuated position, the second spring 10, the shift sleeve 15 and the needle guard 3 move back to the starting position, via the engagement of the locking member 8a and the locking sleeve 8 is taken from the shift sleeve 15.
    To administer the product from the product container 13, the peel cap 4 is removed from the autoinjector together with the rigid needle shield 14. The distal end of the needle guard 3 is attached to the puncture site of a patient, the housing 2 is moved to the puncture site, whereby the needle guard 3 from its initial position to the operating stroke HB (not shown) in the proximal direction relative to the housing. 2 moved to the actuated position. As a result, the second spring 10 is tensioned, wherein the shift sleeve 15 is taken from the needle guard 3 to the operating stroke HB. The locking sleeve 8 has a recess or a distal end 8b which is brought to the position of the second engagement element 6b by displacing the locking sleeve 8 about the actuating stroke HB along the longitudinal axis L. As a result, the first engagement element 6a is moved out of engagement with the advancing member 7 with a movement transversely to and away from the longitudinal axis L, at the same time the second engagement element 6b is moved into engagement with the locking sleeve 8, in particular its recess 8b. As a result, the propulsion member 7 is released for movement about the dispensing stroke HA (not shown) in the dispensing direction.
    Since the axially fixed coupling between the driving member 7 and the holding member 6 is now canceled, the holding member 6, which is at least a little far relative to the housing 2 and along the longitudinal axis L movable from the second spring 10 in the proximal Direction to be moved, wherein the holding member 6 via the engagement of the second engaging member 6b in the recess 8b, the locking sleeve 8 to a start signal stroke HS (not shown) entrains, whereby the locking sleeve 8 abuts a start signal stop, which is formed by the mechanism holder 5, and This emits an acoustic and / or tactile signal, which signals the user of the device that the product distribution was started.
    Since the second engaging member 6b still abuts in the recess 8b of the locking sleeve 8, thereby the retaining member 6 is prevented from moving further in the proximal direction relative to the housing 2 or the locking sleeve 8. The second engaging member 6b is held in engagement with the recess 8b from the outer periphery of the driving member 7 when the driving member 7 is moved around its discharging stroke HA.
    At the end of the dumping stroke HA, the advancing member 7 releases the first engaging member 6a for movement in particular toward the longitudinal axis L, whereby the second engaging member 6b is moved out of engagement with the recess 8b of the locking sleeve 8, so that the second spring 10 moves Holding element 6 against the delivery direction, ie accelerated in the proximal direction, so that upon impact of the holding element 6 on the Endignalanschlag 5e an acoustic and / or tactile signal is generated.
    By removing the autoinjector from the injection site, the second spring 10 can move the shift sleeve 15 and the needle guard 3 from the actuated position to the needle guard position about the needle guard stroke HN. A locking member 8a on the locking sleeve 8, which comes into engagement with the switching sleeve 15, then prevents a further pushing back of the needle guard 3rd
    3a-3c show a first embodiment of a spring assembly according to the invention, as it could be installed, for example, in auto-injector 0 or in the autopen 100 described below. FIGS. 4a-4c show an embodiment with an alternative spiral spring,
    Fig. 3a shows a perspective view of the spring assembly 9, Fig. 3b shows a longitudinal section through the spring assembly 9 and Fig. 3c shows an exploded view of the spring assembly 9. The spring assembly 9 consists basically of four items, the spring shaft 91 with shaft 91a and flange 91b, the coil spring 92, the spring sleeve 93 and the spring sleeve cover 94. The inner end of the coil spring 92c is secured by means of tab in the spring anchor 91d, while the spring 92 can be movably mounted in the axial direction L. The outer end of the spring 92a is fastened by means of tab 92b to the holding device 93d of the spring sleeve 93. Again, a movement in the axial direction L between spring sleeve 93 and spring 92 may be possible. The flange 91 b has one or more radial stops 91 c, in which the Sperrschnapper 93 a can engage by means of tooth 93 g. The locking direction is stop 91c / tooth 93g is chosen so that a relaxation of the spring 92 can be prevented. The spring shaft 91 has a bore or opening 91e in the axial direction L. In the opening, the proximal end of the threaded rod 11 can be rotatably mounted. While the flange 91 b terminates the spring assembly in the distal direction, the spring sleeve cover 94 serves to close in the proximal direction, wherein the spring sleeve cover 94 can be secured in the openings 93 e of the spring sleeve by means of the fixing elements 94 a protruding in the radial direction. The spring assembly of Figs. 4a - 4c differs from the spring assembly of Figs. 3a - 3c with respect to the spring 92nd The comparison between the two variants shows one of the advantages of the construction of the spring assembly 9 according to the invention. Without resulting in structural changes to the spring shank, spring sheath or spring sleeve cover, springs of different sizes can be used deploy. As a result, the delivery device, for example the auto-injector 0 or the autopen 100, does not have to be structurally adapted. Thus, with consistent design of the delivery device, adjustment of the force to be effective in administering a particular drug can take place by merely using a specific adapted spring, alternatively employing a plurality of springs which provide the specific fit. The openings 93e on the spring sleeve 93, which are brought out at different positions, allow the spring sleeve cover 94 to be fastened in the spring sleeve 93 adapted to the width of the spring 92, whereby several covers can also be used in the alternative use of several springs.
    The spring sleeve 93 has in its distal region on the Sperrschnapper 93a and the control arm 93b. Both are parts of the same flexible arm, so that movement of the free end of the control arm 93b in the radial direction results in movement of the free end of the locking catch 93a, in particular the tooth 93g, in the same direction.
    The coil spring 92 can be tensioned by relative rotation of the spring sleeve 93 and the spring shaft 91. In the present example (Figure 3) and seen from the proximal, the spring sleeve 93 is rotated counterclockwise relative to the spring shaft 91 to bias the spring 92 in the winding direction. If the spring 92 is tensioned, the relaxation of the spring 92 can be prevented by the engagement of the locking catch 93a in the radial stop 91c. In a preferred variant, the spring sleeve is formed from a metallic sheet, in which the locking snapper 93a can be brought into plastic deformation with the radial stop. Thus, potential energy can be stored in the spring package and the package can also be transported or stored as bulk material when the spring is tensioned. FIGS. 5a and 5b show a view of the spring assembly 9 from the distal direction, wherein FIG. 5b is an enlarged detail of FIG. 5a. Especially in Fig. 5b, the engagement between tooth 93g and radial stop 91c is very clearly visible.
    6 to 8 show stepwise the installation of the spring assembly 9 in the autoinjector 0, a first step, the spring assembly with the preassembled drive unit (left side Fig. 6) of the auto-injector 0 is brought together, it is important to mention that in particular the advancing member 7 is already secured against rotation in the mechanism holder 5 and also the holding element 6 is mounted so that the advancing member 7 can not be moved in the distal direction. The spring assembly 9 is placed on the proximal end of the threaded rod 11. The cross section of the proximal end of the threaded rod 11 is not circular and the opening 91 e of the spring shaft 91 is complementary to it, so that both parts are secured against rotation to each other. When attaching it must be paid attention to the orientation of the mechanism holder 5, since the release element 5f is to come to rest in front of the control arm 93b, see also Fig. 9b, which illustrates the situation with plugged spring assembly 9 cut. In Fig. 7a, the spring pack is completely brought together with the preassembled drive unit.
    Now the cap 12 is connected via the spring assembly 9 away with the preassembled drive unit. In a nutshell, the mechanism holder 5 and the closure cap 12 are firmly connected to one another via a bayonet closure. Next, the spring sleeve 93 is rotationally connected to the cap 12, it is the locking engagement between Sperrschnapper 93a and radial stop 91c dissolved and in a final step, a rotation of the spring sleeve 93 in the direction of relaxation of the spring 92 by engagement of the block 93i in the radial Stop 5 g of the mechanism holder 5 is suppressed.
    For the bayonet between mechanism holder 5 and cap 12 5 bayonet cams 5h are arranged on the mechanism holder (in the present case there are four, in principle, at least one is needed). Correspondingly complementary bayonet grooves 12b / c are arranged on the inner surface of the closure cap 12, wherein the grooves consist at least of an axially extending portion 12b and a portion 12c extending along the circumference. The cap 12 is now pushed onto the preassembled drive unit so that the bayonet cams 5h are inserted into the grooves 12b. The cap is pushed onto the drive unit so far that the anti-rotation 93h of the spring sleeve engage with anti-rotation 12d of the cap 12, whereby cap 12 and spring sleeve 93 are connected against rotation. Now, the cap 12 is rotated relative to the mechanism holder 5, so that the bayonet cams 5h now move in the grooves 12c. Due to the rotation between closure cap 12 and spring sleeve 93 and the spring sleeve 93 is rotated relative to the mechanism holder 5. As a result, the release members 5f radially raise the associated control arms 93b, thereby also releasing the associated connection between the latching catch 93a and the radial stopper 91c. In an advantageous consequence supports a possible bias of the coil spring 92, the closure movement of the bayonet lock until the block 93i comes into abutment with the radial stop 5g of the mechanism holder, whereby the shutter movement is completed. In this state, the torque of the coil spring 92 is held on the outside over the radial stop 5 g of the mechanism holder 5. On the inside, the torque is transmitted to the threaded rod 11 via the spring shaft 91. The threaded rod 11 is in turn - as described - connected via a threaded connection with the driving member 7, which in turn connected against rotation with the mechanism holder 5, so that the torque is translated into a force which acts axially in the distal direction on the driving member. As shown in Fig. 2b, the driving member 7 is prevented by the engagement of the engagement member 6a in the recess 7a before triggering the autoinjector 0 on a movement in the distal direction. The coil spring 92 is therefore stable even in this phase of assembly of the autoinjector 0, without any existing bias would be lost. The final assembly of the auto-injector 0 can be continued as it is familiar to those skilled in the art.
    The above-described phases of the assembly of preassembled drive unit, spring assembly and closure cap is additionally documented in FIGS. 9a-9d and 10a-10d. FIGS. 9b-9d show how the release element 5f raises the control arm 93b, thereby releasing the connection between the locking catch 93a and the radial stop 91c, and then bringing the radial block 93i of the spring sleeve 93 into engagement with the radial stop 5g of the mechanism holder 5. FIGS. 10b-1dd show the same phases as FIGS. 9b-9d, the cross-section taking place at the level of the locking catch 93a.
    Referring to Figs. 11 to 12b, a second possible delivery device according to the invention with a spring package according to the invention will now be described, based on an automatic injection pen 100 as shown in Fig. 11, the administering device 100 will be referred to simply as autopen. At this point, WO 2015/135 083 is referenced and fully integrated into the present application, since it also conceptually describes the Autopen 100 apart from the spring package.
    The spring assembly 109 is similar to spring assembly 9 built on, corresponding parts and features are marked with an identifier plus 100. As an example, mention may be made of the coil spring 192 of the autopop 100, which corresponds to the coil spring 92 in the case of the autoinjector 0. The same applies to analogous parts in the administering device.
    The autopen 100 is designed to allow the user to administer multiple variable dose injections. When the medicine container 113 is empty, the autopen 100 is discarded as a whole. The coil spring 192 of the spring assembly 109 is designed so that it is biased and the entire drug container 113 can be emptied with the stored energy. The spring assembly 109 is located in the dose setting member 122 at autopen 100. In this case, the spring shaft 191 is rotatably connected to the drive member 111. In the assembled state, as shown in Fig. 12b, the engagement of the radial block 193t of the spring sleeve 193 in the radial stop 105g of the spring retainer 105 prevents relaxation of the coil spring.
    The assembly of the spring assembly 109 and the release of torque from the coil spring 192 takes place analogously almost the same as in the autoinjector 0. During assembly takes over the spring seat 105, the tasks of the mechanism holder 5, the drive member 111 corresponds to the threaded rod 11 and cover 112 corresponds the cap (or housing part) 12. At least dosing 122, spring retainer 105 and drive member 111 are pre-assembled so that all three parts are secured against rotation to each other.
    The geometry of the lid 112 results in a difference in assembly. Instead of a bayonet closure of the lid 112 is connected via a snap connection with the spring receptacle 105. For this purpose, a groove 105h is arranged on the circumference of the spring receptacle 105 and on the inner surface of the lid 112 complementary to a rib 112c. Functionally corresponds to the rib 112c of the bayonet groove 12c of the autoinjector 0. During assembly, first the spring assembly is pushed into the spring receptacle 105 and the spring shaft 191 secured against rotation with the drive member 111 is connected. Thereafter, the lid 112 is snapped onto the spring retainer 105 (which functionally corresponds to the first part of the bayonet locking process in the auto-injector 0), wherein the anti-rotation 112d of the lid 112 must be aligned so that they can engage in the anti-rotation 193h spring sleeve 193. After the lid 112 has snapped clean, the lid 112 can be rotated relative to the spring seat 105, the release elements 105f move the associated control arm 193b radially outward and thus release the engagement of Sperrschnapper 193a and radial stop 191c on spring shaft 191. The torque acting from the coil spring 192 now causes the cover 112 to be rotated together with the spring sleeve 193 relative to the spring receiver 105 until the block 193i of the spring sleeve 193 engages with the radial stop 105 of the spring receiver.
    For the Autopen 100 simpler variants of the assembly are advantageous to design. For example, in one variant, the engagement between the locking catch 193a and the radial stop 191c can be achieved without the cover 112. This can be done so that, after the spring assembly 109 has been inserted into the spring receptacle 105, directly the spring sleeve 193 is rotated relative to the spring receiver and the release elements 105f, as described above, then actuate the control arm. The lid 112 could then be snapped on the spring receptacle 105 then. An anti-rotation 112d / 193h would be obsolete then.
    Further, in a further advantageous simplification would also be conceivable that the control arm would be operated during insertion of the spring assembly 109 in the spring retainer 105 and so no relative rotation between spring sleeve 193 and spring retainer 105 would be necessary to release the torque.
    LIST OF REFERENCE NUMBERS
    [0081]<tb> 0 <SEP> autoinjector, injection device<Tb> 1 <September> syringe holder<Tb> 1a <September> Abragung<Tb> 1b <September> Shoulder<Tb> 1c <September> latching<Tb> 2 <September> Housing<Tb> 2 <September> recess<Tb> 2b <September> Verrastöffnung<Tb> 3 <September> needle guard<tb> 3a <SEP> proximal end<Tb> 4 <September> pull cap<Tb> 4 <September> Snap hooks<Tb> 4f <September> Nadelschutzkappenentferner<Tb> 5 <September> mechanism holder<Tb> 5c <September> holding spring portion<Tb> 5e <September> Endsignalanschlag<Tb> 5f <September> release element<tb> 5g <SEP> radial stop<Tb> 5h <September> bayonet cam<Tb> 6 <September> holding element<tb> 6a <SEP> first engagement element / member<tb> 6b <SEP> second engagement element / member<Tb> 6c <September> Arm<Tb> 6e <September> Abragung<Tb> 7 <September> spurring member / piston rod<Tb> 7 <September> recess<Tb> 7b <September> thread segment<Tb> 8 <September> locking sleeve<Tb> 8 <September> locking member<tb> 8b <SEP> first recess / distal end<Tb> 8c <September> locking arm<Tb> 9 <September> springs<Tb> 91 <September> spring shaft<Tb> 91 <September> End<Tb> 91b <September> flange<tb> 91c <SEP> radial stop<Tb> 91d <September> spring anchor<Tb> 91e <September> opening<Tb> 92 <September> spiral spring<tb> 92 <SEP> alternative coil spring<tb> 92a <SEP> outer end<Tb> 92b <September> retaining tab<tb> 92c <SEP> inner end with retaining tab<Tb> 93 <September> spring sleeve<Tb> 93 <September> Lock snapper<Tb> 93b <September> control arm<Tb> 93c <September> locking element<Tb> 93d <September> holder<Tb> 93e <September> opening<Tb> 93f <September> retaining edge<Tb> 93g <September> tooth<Tb> 93h <September> rotation<tb> 93i <SEP> radial block<Tb> 94 <September> spring casing cover<Tb> 94 <September> fixing<Tb> 10 <September> needle guard spring<Tb> 11 <September> threaded rod<Tb> 12 <September> cap<Tb> 12 <September> locking member<b> 12b <SEP> Bayonet groove, axially extending part<tb> 12c <SEP> Bayonet groove, circumferential part<Tb> 12d <September> rotation<tb> 13 <SEP> product container / syringe<Tb> 13 <September> cannula / needle<tb> 13b <SEP> Piston / Stopper<Tb> 13c <September> finger flange<Tb> 14 <September> needle cap<Tb> 15 <September> switching sleeve<Tb> 15 <September> recess<tb> 100 <SEP> autopen, injection device<Tb> 101 <September> carpule holder<Tb> 102 <September> Housing<Tb> 105 <September> spring mount<Tb> 105f <September> release element<tb> 105g <SEP> radial stop<Tb> 105h <September> Nut<Tb> 107 <September> piston rod<Tb> 107c <September> plunger rod<Tb> 111 <September> drive member<Tb> 112 <September> Lid<Tb> 112c <September> rib<Tb> 112d <September> rotation<Tb> 113 <September> carpule<Tb> 113 <September> injection needle<Tb> 113b <September> Karpulenstopfen<Tb> 109 <September> springs<Tb> 191 <September> spring shaft<Tb> 191 <September> End<Tb> 191b <September> flange<Tb> 192 <September> spiral spring<Tb> 193 <September> spring sleeve<Tb> 193a <September> Lock snapper<Tb> 193b <September> control arm<Tb> 193 h <September> rotation<tb> 193i <SEP> radial block<Tb> 194 <September> spring casing cover<Tb> 122 <September> dose setting<Tb> L <September> longitudinal axis
    权利要求:
    Claims (14)
    [1]
    1. spring package for an administering device, comprisinga spring, which is designed as a drive or spiral spring,a spring shaft with a fixed flange, wherein the inner end of the spring is mounted at least rotationally fixed to the shaft,a spring sleeve which at least partially surrounds the jacket region of the spring, the outer end of the spring being connected in a rotationally fixed manner to the spring sleeve,a disc-like spring sleeve cover which can be fixed axially fixed to the spring sleeve or the spring shaft, wherein the plate diameter of the spring sleeve cover is equal to or smaller than that of the spring sleeve,wherein the spring shaft defines an axis, has a proximal and a distal end, and the flange and spring sleeve covers extend radially away from the axis, wherein the flange is disposed proximate the distal end of the spring shaftcharacterized in thatat least one radial stop is arranged on the periphery of the flange, and at least one blocking means is arranged on the spring sleeve complementary to the at least one radial stop, so that upon engagement of blocking means and radial stop the spring sleeve and the spring shaft are secured against rotation relative to each other and releasably.
    [2]
    2. spring assembly according to claim 1, wherein the axial positioning of the spring by the fixed position of the flange, and a variable axial fixation of the spring sleeve cover is defined and thereby springs with different axial extent in the spring assembly can be used.
    [3]
    3. spring assembly according to claim 2, wherein the spring sleeve cover can be moved into the spring sleeve, wherein the spring sleeve cover has at its periphery at least one snap element, and the spring sleeve complementary thereto at least one receptacle for the at least one snap element to the spring sleeve cover to the spring sleeve fasten.
    [4]
    4. Spring pack according to claim 3, wherein the spring sleeve comprises at least one receptacle for the at least one snap element of the spring sleeve cover at a plurality of axial positions, so that the spring sleeve cover can be secured in different axial positions on the spring sleeve,
    [5]
    5. spring assembly according to one of claims 1 to 4, characterized in that the spring consists of spirally rolled-up strip material, preferably made of metallic strip material, particularly preferably of band-shaped steel.
    [6]
    6. spring assembly according to one of the preceding claims, wherein the spring sleeve is arranged coaxially to the spring shaft, characterized; that at least one flexible arm is arranged on the spring sleeve, which extends in the circumferential direction of the spring sleeve, which is fixedly attached at one end to the spring sleeve and can be deflected in the radial direction at the other end and at the free end of the blocking agent, in particular in Form of a tooth is arranged, which can be brought by deflection of the at least one flexible arm of the flexible arm in engagement with the radial stop or disengaged from the engagement, so that the flexible arm together with the blocking means can form a Sperrschnapper.
    [7]
    7. Spring assembly according to one of the preceding claims, wherein the spring shaft has an axially formed retaining rib, in which the formed as a retaining tab inner end of the spring can be rotatably anchored, and wherein the spring sleeve has an axially oriented support structure on which the formed as a retaining tab outer End of the spring can be anchored rotatably.
    [8]
    8. Spring assembly according to claim 6 and 7, wherein the spring can be biased by relative rotation of the spring sleeve to the spring shaft, and wherein said bias voltage can be maintained by engagement of radial stop and blocking means, and wherein the bias torque of 1 to 100 Nmm may correspond, preferably corresponds to a torque of 30 to 80 Nmm and may particularly preferably correspond to a torque of 60 to 70 Nmm.
    [9]
    9. spring assembly according to claims 6 or 8, wherein offset at the free end of the arm axially in the distal direction to the blocking means a control arm is arranged, and wherein in radial deflection of the control arm and the blocking means is moved radially according to and vice versa.
    [10]
    A delivery device for administering a fluid product comprising the delivery devicea longitudinal axis,a housing with a mechanism holder which is fixedly connected to the housing, a triggering device,a product container, in particular in the form of a prefilled syringe or carpule, which is arranged at least axially fixed in a part of the housing, wherein in the product container an axially displaceable plug is arranged, can be distributed by the displacement in the distal direction product from the product container,a spring assembly according to claim 9, in which energy is stored for the automatic dispensing of product, wherein the spring assembly is operatively connected to the triggering device, and wherein the spring sleeve is rotatably connected to the housing,a coaxial with the longitudinal axis threaded rod, which is rotatably connected to the spring shaft,a piston rod arranged coaxially to the longitudinal axis, which is guided axially displaceably and non-rotatably in the mechanism holder, wherein the piston rod can interact with the plug of the product container so that in axial movement of the piston rod in the distal direction and the plug can be moved in the distal direction,wherein the piston rod is sleeve-like and threadedly on an inner surface of the piston rod in threaded engagement with the threaded rod, so that a rotation of the threaded rod, an axial displacement of the piston rod has the result.
    [11]
    11. A method for mounting a spring assembly with a biased drive or coil spring in an administration device for administering a fluid product, in particular an elongated injection device, comprising a housing and a housing-fixed mechanism holder comprising at least the following steps:a) the spring pack is pushed axially onto a preassembled drive unit of the administering device, which comprises the mechanism holder,whereby a rotatable in the drive unit existing drive member is connected against rotation with a spring shaft of the spring assembly, andwhereby a release element fixedly arranged on the mechanism holder slides in front of a control arm of the spring assembly,b) a housing part or end part of the administering device is pushed axially in the distal direction over the spring assembly,whereby the outer lateral surface of the spring assembly is secured against rotation with the housing part or end part,c) the housing part or end part is rotated relative to spring assembly and preassembled drive unit,whereby the guide elements of the mechanism holder are guided in guides of the housing part or end part, the guide running along the circumference of the housing part or end part,wherein by the rotation of the release member moves the control arm outward in the radial direction and thus releases a torque present in the spring assembly, whereby a further relative rotation between the housing or end part and the mechanism holder evokes to a radial block of the spring assembly in engagement with a radial stop the Mechanic holder device and so a non-positive connection between spring assembly and mechanism holder is generated.
    [12]
    12. An administering device which has been mounted according to a method according to claim 11, wherein the drive or coil spring is wound so that the torque acting on the outer circumferential surface of the spring assembly after the release of the torque compared with the running along the circumference Part of the guide on the housing part facing in the opposite tangential direction.
    [13]
    13. An administering device according to claim 12 or which has been mounted by a method according to claim 11, wherein the administering device is an autoinjector or an injection pen with automatic administration.
    [14]
    14. An administering device according to claim 12 or which has been assembled by a method according to claim 11, wherein the administering device is a «patch» device.
    类似技术:
    公开号 | 公开日 | 专利标题
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    同族专利:
    公开号 | 公开日
    EP3313480A1|2018-05-02|
    EP3313480B1|2021-05-05|
    US20180169346A1|2018-06-21|
    PL3280472T3|2019-08-30|
    CH711269A2|2016-12-30|
    CN107743405B|2020-08-25|
    US10799647B2|2020-10-13|
    CN107743405A|2018-02-27|
    EP3280472A1|2018-02-14|
    DK3313480T3|2021-07-26|
    CN107995872B|2020-12-04|
    CN107995872A|2018-05-04|
    CH711240A2|2016-12-30|
    EP3280472B1|2019-02-27|
    EP3313479B1|2021-08-04|
    US20180110926A1|2018-04-26|
    PL3313480T3|2021-11-02|
    US10561799B2|2020-02-18|
    EP3313479A1|2018-05-02|
    US20210016016A1|2021-01-21|
    WO2016205962A1|2016-12-29|
    WO2016205961A1|2016-12-29|
    WO2016205963A1|2016-12-29|
    WO2016205961A8|2018-02-01|
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    法律状态:
    2019-07-15| AZW| Rejection (application)|
    优先权:
    申请号 | 申请日 | 专利标题
    CH00904/15A|CH711240A2|2015-06-23|2015-06-23|Auto injection device.|CN201680037061.2A| CN107743405B|2015-06-23|2016-06-16|Improved drive unit and injection device|
    DK16734167.6T| DK3313480T3|2015-06-23|2016-06-16|IMPROVED DRIVE UNIT AND INJECTION DEVICE|
    PCT/CH2016/000093| WO2016205963A1|2015-06-23|2016-06-16|Improved drive unit and injection device|
    PL16734167T| PL3313480T3|2015-06-23|2016-06-16|Improved drive unit and injection device|
    EP16734167.6A| EP3313480B1|2015-06-23|2016-06-16|Improved drive unit and injection device|
    US15/850,239| US10561799B2|2015-06-23|2017-12-21|Drive unit and injection device|
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